CHANGES TO MICROBIOLOGY SUSCEPTIBLITY REPORTING

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Reporting of antibiotic susceptibility from microbiology laboratories is changing in line with EUCAST recommendations.   From June 2021, you will see more antibiotics reported as I as well as the more familiar S and R.   The definitions of these are listed below

S

Susceptible at standard dose

I

Susceptible, increased exposure (= increased dose)

R

Resistant even with increased exposure/dose

Agents reported as “I” are still appropriate treatment options when given at the correct (higher) dose.   These higher doses are listed in the table below.  

If in doubt or antibiotic dose not listed below please discuss with clinical microbiologist. 

Drug

Increased Dose             

Benzylpenicillin

1.2g to 2.4g 4-6 hourly
In S. pneumoniae, dose required is specified on reports

Temocillin IV

2g 8 hourly

Piperacillin/tazobactam IV

4.5g 6 hourly

Ceftazidime IV

2g 8 hourly

Aztreonam IV

2g 6 hourly

Co-trimoxazole IV/Oral

1440mg 12 hourly

Amoxicillin Oral

1g 8 hourly

Co-amoxiclav Oral

Co-amoxiclav 625mg 8 hourly
+ Amoxicillin 500mg 8 hourly

Levofloxacin IV/Oral

500mg 12 hourly

Ciprofloxacin IV

400mg 8 hourly

Ciprofloxacin Oral

750mg 12 hourly

Please note these doses are applicable to dosing in adults with normal renal and hepatic function.   In impaired hepatic/renal function please adjust accordingly/discuss with pharmacist.

Aminoglycoside sensitivity reporting has changed in line with EUCAST recommendations.  This does not affect clinical practice, provided patients are improving on therapy.

Editorial Information

Last reviewed: 28 May 2021

Next review: 28 May 2023

Version: 1

Approved By: TAM Subgroup of ADTC

Reviewer Name(s): Alison Macdonald, Area Antimicrobial Pharmacist