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NHS Highland Formulary Chapter 2.8 Oral Anticoagulants
Initial therapeutic dose (oral): rivaroxaban 15mg twice daily for 21 days then maintentance dose: 20mg once daily thereafter.
Adjustment for renal function (see SPC):
Rivaroxaban is contraindicated if creatinine clearance is < 15ml/min. Prescribe alternative therapy.
Moderate (CrCl 30-49mL/min) or severe (CrCl 15-29mL/min) renal impairment: consider reducing maintenance dose from 20 mg once daily to 15 mg once daily if the patient's assessed risk for bleeding outweighs the risk for recurrent DVT and PE. Consider discussing with Haematology.
Mild (CrCl 50-80mL/min) renal impairment: no dosage adjustment necessary.
If active malignancy treat with low molecular weight heparin.
Duration of treatment
All patients should be individually assessed for risk: benefit, but the following should be considered:
First DVT confined to below knee clot (or superficial femoral): 6 weeks to 3 months
First DVT, affecting ileo-femoral veins (except superficial femoral): 3-6 months. (3 months usually appropriate for temporary risk factors and low risk of recurrence, 6 months for idiopathic DVT or permanent risk factors)
Recurrent DVT (or previous PE): 6 months and consider life-long anticoagulation (usually by switching from Rivaroxaban to Warfarin after 3 months. Discuss with haematology)
Rivaroxaban contraindicated: start enoxaparin subcutaneous injections
Enoxaparin 1.5 mg/kg once daily (rounded to the nearest 10mg) for uncomplicated patients with low risk of VTE recurrence.
Enoxaparin 1 mg/kg twice daily should be used in all other patients such as those with obesity, symptomatic PE, cancer, recurrent VTE or proximal thrombosis.
Adjust dose in renal impairment (eGFR less than 30ml/min/1.73m2), see SPC for details.
If both contraindicated please contact Haematology via Raigmore switchboard (01463 704000).
Graduated compression stockings should be sized and prescribed for all confirmed DVTs, to be worn for 6 months post-diagnosis to reduce the risk of post-phlebetic leg syndrome.
General note: Consider need for investigation of cause of DVT (occult malignancy should be considered, but if there are no warning symptoms, and physical examination (including PR) is normal, further investigation is not usually appropriate. Thrombophilia screening in unexplained events in younger people should be discussed with haematology, and is usually done after anticoagulation warfarin is discontinued).
Last reviewed: 31 August 2013
Next review: 31 August 2015
Author(s): Consultant Physician, Consultant Haematologist, Consultant Radiologist
Approved By: High-UHB.firstname.lastname@example.org
Reviewer Name(s): Dr Grant Franklin